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1

Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked-X Four-Way Junction by a Small Molecule

Anna L. Brogden, Nicholas H. Hopcroft, Mark Searcey, Christine J. Cardin

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 4.79 MB

english, 2007

2

A small molecule that induces assembly of a four way DNA junction at low temperature

Howell, Lesley A., Waller, Zoë A. E., Bowater, Richard, O'Connell, Maria, Searcey, Mark

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

3

Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain

Dale L Boger, Brian M Aquila, Winston C Tse, Mark Searcey

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 743 KB

english, 2000

4

Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu, Searcey, Mark, Jin, Qing

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

5

A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Petros G Tsoungas, Mark Searcey

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 74 KB

english, 2001

6

Design and synthesis of threading intercalators to target DNA

Lesley A. Howell, Rosul Gulam, Anja Mueller, Maria A. O’Connell, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 452 KB

english, 2010

7

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark, Patterson, Laurence H.

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

8

DNA Binding by Analogues of the Bifunctional Intercalator TANDEM

Hampshire, Andrew J., Rusling, David A., Bryan, Stephanie, Paumier, David, Dawson, Simon J., Malkinson, John P., Searcey, Mark, Fox, Keith R.

Journal:

Year:

2008

Language:

english

File:

PDF, 9.43 MB

english, 2008

9

Duocarmycins - Natures Prodrugs?

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 87 KB

english, 2002

10

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

Dr. Lesley A. Howell, Dr. Richard A. Bowater, Dr. Maria A. O'Connell, Anthony P. Reszka, Prof. Stephen Neidle, Prof. Mark Searcey

Journal:

Year:

2012

Language:

english

File:

PDF, 690 KB

english, 2012

11

Solid-Phase Synthesis of the Cyclic Peptide Portion of Chlorofusin, an Inhibitor of p53-MDM2 Interactions

Malkinson, John P., Zloh, Mire, Kadom, Mohanad, Errington, Rachel, Smith, Paul J., Searcey, Mark

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

12

The solid phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity.

Stephenson, Michael J, Howell, Lesley A., O'Connell, Maria A., Fox, Keith R, Adcock, Claire, Kingston, Jenny, Sheldrake, Helen, Pors, Klaus, Collingwood, Stephen P, Searcey, Mark

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 892 KB

english, 2015

13

Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

Kenji Watanabe, Kinya Hotta, Alex P. Praseuth, Mark Searcey, Clay C. C. Wang, Hiroki Oguri, Hideaki Oikawa

Journal:

Year:

2009

Language:

english

File:

PDF, 267 KB

english, 2009

14

DNA threading agents: effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides

Mark Searcey, P. Noel Martin, Nicola M. Howarth, Bernie Madden, Laurence P.G. Wakelin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

15

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

Dale L. Boger, Mark Searcey, Winston C. Tse, Qing Jin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

16

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction

Clark, Ryan C., Lee, Sang Yeul, Searcey, Mark, Boger, Dale L.

Journal:

Natural Product Reports

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

17

Solid-Phase Synthesis of Chlorofusin Analogues

Woon, Esther C. Y., Arcieri, Mariangela, Wilderspin, Andrew F., Malkinson, John P., Searcey, Mark

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 378 KB

english, 2007

18

Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Containing Modifications in the Subunit Linking Amide

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Jin, Qing

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 148 KB

english, 1999

19

A rapid screen for molecules that form duplex to duplex crosslinks in DNA

Marín, María J., Rackham, Benjamin D., Round, Andrew N., Howell, Lesley A., Russell, David A., Searcey, Mark

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

20

ChemInform Abstract: Targeting Higher-Order DNA: Beyond the G-Quadruplex

Lesley A. Howell, Mark Searcey

Journal:

Year:

2009

File:

PDF, 15 KB

2009

21

Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

Dale L. Boger, Christopher W. Boyce, Robert M. Garbaccio, Mark Searcey

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 295 KB

english, 1998

22

A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents

Austin, Michael, Hearnshaw, Stephen, Mitchenall, Lesley, McDermott, Paul, Howell, Lesley Ann, Maxwell, Tony, Searcey, Mark

Journal:

Year:

2016

Language:

english

File:

PDF, 896 KB

english, 2016

23

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

Steel, Richard, Cowan, Jonathan, Payerne, Estelle, O'Connell, Maria A., Searcey, Mark

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.86 MB

english, 2012

24

Efficient Solid-Phase-Based Total Synthesis of the Bisintercalator TANDEM

Malkinson, John P., Anim, Michael K., Zloh, Mire, Searcey, Mark, Hampshire, Andrew J., Fox, Keith R.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 414 KB

english, 2005

25

Critical Role of the Linking Amide in CC-1065 and the Duocarmycins: Implications on the Source of DNA Alkylation Catalysis

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Jin, Qing

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 152 KB

english, 1998

26

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

Waller, Zoë A.E., Howell, Lesley A., MacDonald, Colin J., O’Connell, Maria A., Searcey, Mark

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 503 KB

english, 2014

27

The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration

Mullins, Robert F., McGwin, Gerald, Searcey, Karen, Clark, Mark E., Kennedy, Elizabeth L., Curcio, Christine A., Stone, Edwin M., Owsley, Cynthia

Journal:

Year:

2018

Language:

english

File:

PDF, 929 KB

english, 2018

28

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley A. Howell, Aaron Howman, Maria A. O’Connell, Anja Mueller, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

29

Truncated azinomycin analogues intercalate into DNA

Maxwell A. Casely-Hayford, Klaus Pors, Laurence H. Patterson, Clive Gerner, Stephen Neidle, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

30

The Handbook of Medicinal Chemistry-Principles and Practice. Edited by Andrew Davis and Simon E. Ward

Journal:

Year:

2015

Language:

english

File:

PDF, 253 KB

english, 2015

31

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties

Williams, Morwen, Green, Adam I., Fernandez-Cestau, Julio, Hughes, David L., O'Connell, Maria Anne, Searcey, Mark, Bertrand, Benoît, Bochmann, Manfred

Journal:

Dalton Transactions

Year:

2017

Language:

english

File:

PDF, 1.60 MB

english, 2017

32

Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design

Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo, Jesus, Searcey, Mark

Journal:

Chemical Science

Year:

2019

File:

PDF, 1.06 MB

2019

33

Synthesis and Evaluation of 1,2,8,8a-Tetrahydrocyclopropa[ c ]pyrrolo[3,2- e ]indol-4(5 H )-one, the Parent Alkylation Subunit of CC-1065 and the Duocarmycins: Impact of the Alkylation Subunit Substituents and Its Implications for DNA Alkylation Catalysis

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Brunette, Steven R., Wolkenberg, Scott E., Hedrick, Michael P., Jin, Qing

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 356 KB

english, 2000

34

ChemInform Abstract: The Isolation, Total Synthesis and Structure Elucidation of Chlorofusin, a Natural Product Inhibitor of the p53—MDM2 Protein—Protein Interaction

Ryan C. Clark, Sang Yeul Lee, Mark Searcey, Dale L. Boger

Journal:

Year:

2009

File:

PDF, 11 KB

2009

35

Unveiling the “Three-Finger Pharmacophore” Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach

Angulo, Jesus, Goffin, Sarah A., Gandhi, Daivik, Searcey, Mark, Howell, Lesley A.

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

36

Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

Ryan C. Clark, Sang Yeul Lee, Inkyu Hwang, Mark Searcey, Dale L. Boger

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 256 KB

english, 2009

37

ChemInform Abstract: Bifunctional Alkylating Agents Derived from Duocarmycin SA: Potent Antitumor Activity with Altered Sequence Selectivity.

Dale L. Boger, Mark Searcey, Winston C. Tse, Qing Jin

Journal:

Year:

2000

File:

PDF, 30 KB

2000

38

Catalytic antibody activity elicited by active immunisation : Evidence for natural variation involving preferential stabilization of the transition state

Gerard GALLACHER, Caroline S. JACKSON, Mark SEARCEY, Rajiv GOEL, Geoffrey W. MELLOR, Carmen Z. SMITH, Keith BROCKLEHURST

Journal:

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

39

ChemInform Abstract: A Convenient Access to Benzo-Substituted Phthalazines as Potential Precursors to DNA Intercalators.

Petros G. Tsoungas, Mark Searcey

Journal:

Year:

2002

File:

PDF, 31 KB

2002

40

ChemInform Abstract: Synthesis and Evaluation of 9-Aminoacridines Derived from Benzyne Click Chemistry.

Lesley A. Howell, Aaron Howman, Maria A. O'Connell, Anja Mueller, Mark Searcey

Journal:

Year:

2010

File:

PDF, 40 KB

2010

41

Chemistry in Cancer Research: A Vital Partnership

Sturla, Shana J., Irwin, John J., Loeppky, Richard N., Mulvihill, Mark J., Searcey, Mark

Journal:

ACS Chemical Biology

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

42

A mild procedure for the production of secondary amines from oximes and benzisoxazoles

Mark Searcey, Sukhwant S. Grewal, Fiorenza Madeo, Petros G. Tsoungas

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

43

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark, Neidle, Stephen

Journal:

Organic & Biomolecular Chemistry

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

44

Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide

Marie-Hélène David-Cordonnier, Maxwell Casely-Hayford, Mostafa Kouach, Gilbert Briand, Laurence H. Patterson, Christian Bailly, Mark Searcey

Journal:

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

45

Design and synthesis of a DNA-crosslinking azinomycin analogue

Casely-Hayford, Maxwell A., Pors, Klaus, James, Colin H., Patterson, Laurence H., Hartley, John A., Searcey, Mark

Journal:

Organic & Biomolecular Chemistry

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

46

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction

Steel, Richard J., O'Connell, Maria A., Searcey, Mark

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 797 KB

english, 2018

47

Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

Williams, Morwen, Bertrand, Benoît, Fernández-Cestau, Julio, Waller, Zoe Ann Ella, O'Connell, Maria Anne, Searcey, Mark, Bochmann, Manfred

Journal:

Dalton Transactions

Year:

2018

Language:

english

File:

PDF, 1.28 MB

english, 2018

48

Cyclometallated Au( iii ) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

Williams, Morwen R. M., Bertrand, Benoît, Hughes, David L., Waller, Zoë A. E., Schmidt, Claudia, Ott, Ingo, O’Connell, Maria, Searcey, Mark, Bochmann, Manfred

Journal:

Year:

2018

Language:

english

File:

PDF, 2.42 MB

english, 2018

49

Targeting Higher-Order DNA: Beyond the G-Quadruplex

Lesley A. Howell, Mark Searcey

Journal:

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

50

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Vinader, Victoria, Sadiq, Maria, Sutherland, Mark, Huang, Mengying, Loadman, Paul M., Elsalem, Lina, Shnyder, Steven D., Cui, Hongjuan, Afarinkia, Kamyar, Searcey, Mark, Patterson, Laurence H., Pors,

Journal:

Year:

2015

Language:

english

File:

PDF, 689 KB

english, 2015

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